Yes, you can keep two bristlenose plecos together. However, bristlenose plecos are actually solitary, highly territorial fish. If you wish to keep two bristlenose plecos together in the same tank, there are some things you need to consider:
First, consider keeping a male-female pair or two females. Never keep more than one male bristlenose pleco in a tank, as they’re very territorial and won’t hesitate to fight each other.
Second, you also need to provide them with enough space to avoid conflicts. Two bristlenose plecos require a 35-gallon tank or larger to live comfortably. You should also keep plenty of live plants, miniature caves, and hiding spots in the tank.